The research is aimed to study the effect of the anti-diabetic drugs Glipizide, Metforminin individually and in combination on blood glucose levels. Initially different generic formulations of Glipizide (G1-G3), Metformin (M1-M3) and formulations containing the combination of Glipizide-Metformin (GM1-GM3) are available in Indian market, were evaluated for various quality control tests including the in-vitro drug release studies. Among these formulations, G1 (Glipizide) showed a high drug release of 98.98±1.54, M1 (Metformin) and Glipizide-Metformin combination showed drug release of 98.72±1.65 and 99.64±1, 98-99.69±1.39 respectively at the end of 20 minutes. These G1, M1 and GM2 formulations were further evaluated for in-vivo studies. In-vivo studies were performed to study the pharmacodynamic changes between two drugs and also for co-administration of formulations containing same active ingredient. The results ascertain that of all four treatments, combination of Glipizide-Metformin had shown considerable results (45.1±1.05, % reduction in blood glucose level) when compared to remaining three treatments.
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